Among the living, society has changed. Witchcraft brings a charge of death; pagan sacrifice is outlawed. The Christian martyrs are heroes of the past; those who would suffer and die for their faith must inflict it upon themselves or each other.
In the meantime, the Christians fight amongst themselves. Constantine stood by the decision of the Nicene council and most of his sons are Nicenes. But the last son of Constantine, the current Emperor Constantius, is an Arian. He's made enemies in the church and advanced his own faction, even going so far as to exile the Bishop of Rome for failing to condemn the troublemaker Athanasius. Constantius has installed his own "anti-Pope," Felix. The two major Christian factions exist on a knife-edge. The city could erupt at any time.
All it needs is one small event, one tiny moment that could start a citywide war.
In the middle of all this, the Emperor comes to Rome. By day, he rides in procession through the streets; by night, he holds court in the long-vacant Palatine. He's not one for revels, and the music is somber and reverent: the sound of hymns travels across the South and West of the city, that and the screams of the tortured hundreds who suffer from accusations of witchcraft and treachery.
Although the animal hunts and games go on far into the night, soldiers, priests and cenobites fill the streets. It's no good time to hunt.
A preacher and a woman who may be some kind of saint appear into the midst of the characters' hunting ground. There is a brothel, a reliable and frequent source of sustenance; within a day of their arrival, the madam and her girls renounced their sinful ways and decided to follow Christ; they cut their hair and burn their dresses, smash jars containing their make-up and perfume and white-wash the brothel walls.
They publicly renounce their past lives. Each reads out a confession of guilt; each lists her clients; each burns her possessions. Then they retire to the former brothel, now a convent under the care of the preacher and his saint, and then they starve themselves nearly to death; they submit themselves to confinement and torture, the better to be pure.
The vampires watch with interest. Some consider that perhaps a convent would be a fine toy, a pretty thing to play with and use for pleasure. Others think that it's an abomination, a means of keeping prey out of the claws of the Kindred. And some of the Sanctified think it's how things should be, that the new nuns are doing the right thing, and that it's the duty of the true believers among the dead to perfect them further by terrorizing them, by adding to their divine sufferings.
The city's Arians, too, represented by the deacon Damasus, watch the development with horror, reasoning that a Nicene saint and a redeemed brothel gives the Nicene heretics too much credit, too much power. And the talk of miracles that can't be true! They're not supposed to do that. It has to be some kind of Satanic perversion, some deception.
Or maybe it's witchcraft.
The conversion of the brothel happens in the middle of the characters' rightful territory, and the area around the brothel, if not the brothel itself, was a prime hunting ground. The characters have to decide what to do: their land, their hunting ground has been compromised.
Meanwhile, the Sanctified vampires are moving in. Narses wants to gain control of the place, and characters may object to having their former hunting grounds overtaken by the Sanctified, whether or not they're members of that faction.